DOK7

Across TCGA pan-cancer cohorts, DOK7 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DOK7 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DOK7 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DOK7 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

GBM, UCS, and LUAD are the cancer types where DOK7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	1.000	0.191	.022	6	view →
UCS	DFS	Median	All	0.126	0.523	.009	6	view →
LUAD	OS	Median	All	0.111	0.359	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DOK7–GBM (DFS)

Open the GBM breakdown →