DOK7

Across TCGA cell cohorts, DOK7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,053 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DOK7-associated GO terms across cancer lineages are Serotonin production involved in inflammatory response, Serotonin secretion involved in inflammatory response, and Serotonin secretion. Each is linked with DOK7 in more than 8 cancer types. Because this analysis shows association rather than direction, both DOK7-to-partner and partner-to-DOK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonin production involved in inflammatory response grouped by DOK7-low versus DOK7-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK7→partner) and Y-score (partner→DOK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Serotonin production involved in inflammatory response →	+1.961	+1.960	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Serotonin secretion involved in inflammatory response →	+1.961	+1.960	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Serotonin secretion →	+1.961	+1.960	<.001	<.001	3	9
URINARY_TRACT	Negative regulation of actin filament polymerization →	+0.135	+2.097	.002	<.001	3	8
URINARY_TRACT	Positive regulation of iron ion transport →	+1.888	+2.057	<.001	<.001	3	8
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+1.888	+2.057	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,053 associations by consensus.

Serotonin production involved in inflammatory response by DOK7 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →