DOK7

Across TCGA cell cohorts, DOK7 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOK7-associated genes across cancer lineages are NPVF, CST11, and TAAR8. Each is linked with DOK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK7-to-partner and partner-to-DOK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by DOK7-low versus DOK7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK7→partner) and Y-score (partner→DOK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NPVF →	+0.029	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CST11 →	+0.089	+4.887	.003	.009	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	HTR5A →	+0.029	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	DYDC1 →	+0.045	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP10-3 →	+0.035	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

NPVF by DOK7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →