DOK5

Across TCGA pan-cancer cohorts, DOK5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DOK5 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DOK5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DOK5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

MESO, SCLC, and LUAD are the cancer types where DOK5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.077	0.580	<.001	42	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
LUAD	OS	Median	II,III,IV	0.111	0.750	<.001	12	view →
UCEC	DFS	Median	II,III,IV	0.928	0.435	.019	10	view →
ESCA	OS	Median	II,III,IV	0.248	0.686	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DOK5–MESO (OS)

Open the MESO breakdown →