DOK5

Across TCGA cell cohorts, DOK5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,656 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DOK5-associated GO terms across cancer lineages are Energy derivation by oxidation of organic compounds, Regulation of proteasomal protein catabolic process, and Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Each is linked with DOK5 in more than 7 cancer types. Because this analysis shows association rather than direction, both DOK5-to-partner and partner-to-DOK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Energy derivation by oxidation of organic compounds grouped by DOK5-low versus DOK5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK5→partner) and Y-score (partner→DOK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Energy derivation by oxidation of organic compounds →	+0.058	+0.866	.001	<.001	3	8
SOFT_TISSUE	Regulation of proteasomal protein catabolic process →	+0.044	+0.957	<.001	.002	3	7
OVARY	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum →	+0.065	+1.900	.002	.002	3	7
BLOOD_Lymphoma	Proton motive force-driven mitochondrial ATP synthesis →	+0.048	+0.698	.003	.007	3	7
SOFT_TISSUE	Regulation of macroautophagy →	+0.062	+1.100	<.001	.002	3	6
CNS	Golgi vesicle transport →	+0.039	+1.263	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,656 associations by consensus.

Energy derivation by oxidation of organic compounds by DOK5 expression — SKIN

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