DOK5

Across TCGA cell cohorts, DOK5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOK5-associated genes across cancer lineages are ZNF831, SIX3, and VAX1. Each is linked with DOK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK5-to-partner and partner-to-DOK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by DOK5-low versus DOK5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK5→partner) and Y-score (partner→DOK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.011	+3.103	<.001	.004	3	1
LARGE_INTESTINE	SIX3 →	+0.743	+3.584	<.001	.003	3	1
LARGE_INTESTINE	VAX1 →	+0.632	+3.519	.001	.007	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+3.518	.001	.001	3	1
BLOOD_Lymphoma	CEACAM4 →	+0.051	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	USP17L1 →	+0.019	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ZNF831 by DOK5 expression — LARGE_INTESTINE

Explore this box plot interactively →