DOK3

Across TCGA pan-cancer cohorts, DOK3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DOK3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DOK3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DOK3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where DOK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.802	1.000	.021	48	view →
CCRCC	DFS	Median	III,IV	0.297	0.706	.001	31	view →
PDAC	DFS	Tertile	II,III,IV	0.563	0.880	.002	20	view →
GBM	OS	Quartile	All	0.325	0.686	.002	6	view →
LUAD	OS	Median	III,IV	0.435	0.777	.007	5	view →
LSCC	OS	Quartile	III,IV	0.970	0.651	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DOK3–COAD (DFS)

Open the COAD breakdown →