DOK3

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DOK3 protein abundance is significantly associated with the RNA expression of many other genes, with 22,385 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DOK3-associated genes across cancer lineages are CYTH4, NCF4, and SIRPB1. Each is linked with DOK3 in more than 8 cancer types. Because this analysis shows association rather than direction, both DOK3-to-partner and partner-to-DOK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOK3 versus CYTH4 in GBM, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK3→partner) and Y-score (partner→DOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCYTH4 →+1.149+0.718<.001<.00139
GBMNCF4 →+1.310+0.760<.001<.00139
COADSIRPB1 →+0.725+0.804<.001<.00139
GBMTLR8 →+1.204+0.684<.001<.00139
UCECTNFSF13B →+1.163+0.596<.001<.00139
GBMAQP9 →+1.748+0.646<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 22,385 associations by consensus.

DOK3 vs CYTH4 — GBM

Per-sample scatter of DOK3 vs CYTH4 in GBM (Pearson r = 0.82).

Explore this scatter interactively →

Exploration