DOK3

Across TCGA patient cohorts, DOK3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOK3-associated genes across cancer lineages are eEF2, A-Raf_pS299, and ERK2. Each is linked with DOK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK3-to-partner and partner-to-DOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DOK3-low versus DOK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK3→partner) and Y-score (partner→DOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.274	+2.999	.037	.035	3	1
UCEC	A-Raf_pS299 →	-0.096	-1.502	.028	.030	3	1
UCEC	ERK2 →	+0.181	+1.847	.010	.008	3	1
UCEC	FOXO3a_pS318_S321 →	-0.091	-1.502	.046	.030	3	1
UCEC	IGFBP2 →	-0.515	-3.321	.031	.009	3	1
UCEC	MAPK_pT202_Y204 →	-0.392	-2.115	.023	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by DOK3 expression — UCEC

Explore this box plot interactively →