DOK3

Across TCGA cell cohorts, DOK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,005 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DOK3-associated GO terms across cancer lineages are Microtubule nucleation, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Double-strand break repair via nonhomologous end joining. Each is linked with DOK3 in more than 13 cancer types. Because this analysis shows association rather than direction, both DOK3-to-partner and partner-to-DOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by DOK3-low versus DOK3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK3→partner) and Y-score (partner→DOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Microtubule nucleation →	+0.169	+1.458	<.001	<.001	3	13
SOFT_TISSUE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.153	+1.331	<.001	<.001	3	13
PANCREAS	Double-strand break repair via nonhomologous end joining →	+0.053	+0.743	.001	.006	2	14
LARGE_INTESTINE	Microtubule polymerization or depolymerization →	+0.129	+1.251	<.001	<.001	3	12
SOFT_TISSUE	Nuclear export →	+0.120	+1.611	<.001	<.001	3	12
STOMACH	Epigenetic regulation of gene expression →	+0.070	+1.796	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,005 associations by consensus.

Microtubule nucleation by DOK3 expression — LARGE_INTESTINE

Explore this box plot interactively →