DOK2

Across TCGA patient cohorts, DOK2 protein abundance is significantly associated with the RNA expression of many other genes, with 19,089 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DOK2-associated genes across cancer lineages are CYTH4, GRAP2, and NCF4. Each is linked with DOK2 in more than 9 cancer types. Because this analysis shows association rather than direction, both DOK2-to-partner and partner-to-DOK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOK2 versus CYTH4 in HNSC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK2→partner) and Y-score (partner→DOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYTH4 →	+1.143	+0.602	<.001	<.001	3	10
HNSC	GRAP2 →	+0.958	+0.571	<.001	<.001	3	10
GBM	NCF4 →	+1.075	+0.850	<.001	<.001	3	10
BRCA	CSF2RB →	+1.202	+0.652	<.001	<.001	3	10
OV	IL2RB →	+1.278	+0.502	<.001	<.001	3	10
HNSC	HCK →	+1.146	+0.610	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,089 associations by consensus.

DOK2 vs CYTH4 — HNSC

Explore this scatter interactively →