DOK2

Across TCGA patient cohorts, DOK2 mutation is significantly associated with the RNA expression of many other genes, with 1,353 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOK2-associated genes across cancer lineages are RNU6-338P, MIR548AQ, and NECAP1P1. Each is linked with DOK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK2-to-partner and partner-to-DOK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-338P grouped by DOK2-low versus DOK2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK2→partner) and Y-score (partner→DOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-338P →	+0.382	+5.523	<.001	.001	3	2
LUAD	MIR548AQ →	+0.650	+4.802	.009	.001	3	2
LUSC	NECAP1P1 →	+0.102	+4.350	.002	.002	3	2
LUSC	RN7SL654P →	+0.162	+5.742	<.001	.001	3	2
COAD	MIR629 →	+0.710	+5.392	<.001	.002	3	2
COAD	RNU4-30P →	+0.552	+4.602	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,353 associations by consensus.

RNU6-338P by DOK2 expression — LUAD

Explore this box plot interactively →