DOK2

Across TCGA patient cohorts, DOK2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOK2-associated genes across cancer lineages are ATM, mTOR_pS2448, and PI3K-p110-a. Each is linked with DOK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOK2-to-partner and partner-to-DOK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DOK2-low versus DOK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK2→partner) and Y-score (partner→DOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.555	-4.169	.002	<.001	3	3
UCEC	mTOR_pS2448 →	-0.137	-3.439	.022	.005	3	2
UCEC	PI3K-p110-a →	-0.153	-3.321	.031	.010	3	2
UCEC	Chk2 →	-0.221	-1.906	.018	.016	3	2
UCEC	ERK2 →	+0.220	+3.459	.004	.005	3	1
UCEC	ETS-1 →	+0.379	+3.700	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by DOK2 expression — UCEC

Explore this box plot interactively →