DOK2

Across TCGA cell cohorts, DOK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,929 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DOK2-associated GO terms across cancer lineages are Nucleus localization, Late endosome to vacuole transport via multivesicular body sorting pathway, and Late endosome to vacuole transport. Each is linked with DOK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DOK2-to-partner and partner-to-DOK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleus localization grouped by DOK2-low versus DOK2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK2→partner) and Y-score (partner→DOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Nucleus localization →	+0.074	+0.032	<.001	.004	3	5
BLOOD_Leukemia	Late endosome to vacuole transport via multivesicular body sorting pathway →	+0.058	+1.690	<.001	<.001	3	5
BLOOD_Leukemia	Late endosome to vacuole transport →	+0.056	+2.028	<.001	<.001	3	5
BLOOD_Leukemia	Endosome transport via multivesicular body sorting pathway →	+0.067	+2.045	<.001	<.001	3	5
BLOOD_Leukemia	Actomyosin contractile ring organization →	+0.118	+2.401	<.001	<.001	3	5
BLOOD_Leukemia	Membrane repolarization →	-0.124	-1.857	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,929 associations by consensus.

Nucleus localization by DOK2 expression — BREAST

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