DOK2

Across TCGA cell cohorts, DOK2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DOK2-associated genes across cancer lineages are GFRA4, MYOD1, and CRYAA. Each is linked with DOK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK2-to-partner and partner-to-DOK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by DOK2-low versus DOK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK2→partner) and Y-score (partner→DOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFRA4 →	+0.295	+4.409	.001	.005	3	1
BLOOD_Leukemia	MYOD1 →	+0.024	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	CRYAA →	+0.049	+4.705	.006	.003	3	1
BLOOD_Leukemia	CCKAR →	+0.038	+4.409	<.001	.005	3	1
BLOOD_Leukemia	GPR101 →	+0.133	+4.551	<.001	.004	3	1
BLOOD_Leukemia	NPAP1 →	+0.104	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GFRA4 by DOK2 expression — BLOOD_Leukemia

Explore this box plot interactively →