DOK1

Across TCGA pan-cancer cohorts, DOK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DOK1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DOK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DOK1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where DOK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.789	1.000	.004	32	view →
PDAC	DFS	Median	III,IV	0.316	0.743	.004	10	view →
LSCC	OS	Median	All	0.923	1.000	.013	9	view →
HNSC	DFS	Quartile	All	0.417	0.667	.017	3	view →
GBM	DFS	Median	All	0.408	0.219	.039	2	view →
LUAD	DFS	Tertile	All	0.639	0.926	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DOK1–CCRCC (OS)

Open the CCRCC breakdown →