DOK1

Across TCGA patient cohorts, DOK1 protein abundance is significantly associated with the RNA expression of many other genes, with 22,022 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DOK1-associated genes across cancer lineages are MNDA, FCGR3A, and PIK3CG. Each is linked with DOK1 in more than 7 cancer types. Because this analysis shows association rather than direction, both DOK1-to-partner and partner-to-DOK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOK1 versus MNDA in HNSC, with a Pearson correlation of 0.23.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK1→partner) and Y-score (partner→DOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MNDA →	+1.249	+0.181	<.001	.008	3	8
HNSC	FCGR3A →	+1.273	+0.264	.001	.001	3	8
LSCC	PIK3CG →	+0.827	+0.252	<.001	<.001	3	8
HNSC	CXorf21 →	+1.151	+0.282	<.001	<.001	3	8
HNSC	LST1 →	+1.387	+0.302	<.001	<.001	3	8
HNSC	CYTH4 →	+1.365	+0.292	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,022 associations by consensus.

DOK1 vs MNDA — HNSC

Explore this scatter interactively →