DOK1

Across TCGA patient cohorts, DOK1 mutation is significantly associated with the RNA expression of many other genes, with 1,050 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOK1-associated genes across cancer lineages are RNU6-711P, NUP50, and DDTL. Each is linked with DOK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK1-to-partner and partner-to-DOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-711P grouped by DOK1-low versus DOK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK1→partner) and Y-score (partner→DOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-711P →	+0.222	+3.292	<.001	.006	3	2
UCEC	NUP50 →	+0.690	+2.823	<.001	.001	3	2
UCEC	DDTL →	+0.358	+2.032	.006	.005	3	2
UCEC	EIF2B1 →	+0.313	+3.609	.009	.001	3	2
UCEC	E2F8 →	+0.871	+3.815	<.001	<.001	3	2
UCEC	NOM1 →	+0.427	+2.523	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,050 associations by consensus.

RNU6-711P by DOK1 expression — SKCM

Explore this box plot interactively →