DOK1

Across TCGA cell cohorts, DOK1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOK1-associated genes across cancer lineages are GRM6, SLCO1C1, and COX6A2. Each is linked with DOK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK1-to-partner and partner-to-DOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM6 grouped by DOK1-low versus DOK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK1→partner) and Y-score (partner→DOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRM6 →	+0.075	+3.115	<.001	.004	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.532	+4.035	<.001	<.001	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ENPP6 →	+0.032	+3.115	.002	.004	3	1
LARGE_INTESTINE	OR1K1 →	+0.038	+3.069	.004	.005	3	1
LARGE_INTESTINE	PHOX2A →	+0.048	+3.617	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GRM6 by DOK1 expression — LARGE_INTESTINE

Explore this box plot interactively →