DOCK9

Across TCGA pan-cancer cohorts, DOCK9 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DOCK9 data layer compared with 28 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DOCK9 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DOCK9 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and OV are the cancer types where DOCK9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.763	0.385	.004	26	view →
UCEC	OS	Tertile	All	0.969	0.787	.013	16	view →
OV	DFS	Tertile	All	1.000	0.836	.042	8	view →
LUAD	OS	Quartile	All	0.831	0.631	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DOCK9–CCRCC (DFS)

Open the CCRCC breakdown →