DOCK9

Across TCGA patient cohorts, DOCK9 mutation is significantly associated with the RNA expression of many other genes, with 5,567 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK9-associated genes across cancer lineages are KIR3DL1, TTC39C-AS1, and TRDJ4. Each is linked with DOCK9 in more than 3 cancer types. Because this analysis shows association rather than direction, both DOCK9-to-partner and partner-to-DOCK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR3DL1 grouped by DOCK9-low versus DOCK9-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK9→partner) and Y-score (partner→DOCK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	KIR3DL1 →	+0.083	+3.497	.002	.007	3	3
UCEC	TTC39C-AS1 →	-0.353	-1.563	.003	.008	3	3
CESC	TRDJ4 →	+0.657	+3.027	<.001	.003	3	3
UCEC	RMND1 →	+0.338	+1.686	.001	.001	3	3
UCEC	CCT8 →	+0.310	+1.955	.001	<.001	3	3
UCEC	APEH →	+0.289	+1.121	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,567 associations by consensus.

KIR3DL1 by DOCK9 expression — READ

Explore this box plot interactively →