DOCK9

Across TCGA patient cohorts, DOCK9 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK9-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eIF4E. Each is linked with DOCK9 in more than 4 cancer types. Because this analysis shows association rather than direction, both DOCK9-to-partner and partner-to-DOCK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DOCK9-low versus DOCK9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK9→partner) and Y-score (partner→DOCK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.508	-1.469	<.001	<.001	3	5
UCEC	Caspase-7-cleavedD198 →	+0.388	+1.736	.011	.005	3	5
UCEC	eIF4E →	+0.197	+1.469	<.001	<.001	3	3
COAD	FASN →	+0.550	+3.169	.001	.018	3	3
COAD	Cyclin-E2 →	+0.563	+2.832	<.001	.034	3	3
UCEC	4E-BP1 →	+0.275	+1.469	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ATM by DOCK9 expression — UCEC

Explore this box plot interactively →