DOCK9

Across TCGA cell cohorts, DOCK9 mutation is significantly associated with the RNA expression of many other genes, with 586 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DOCK9-associated genes across cancer lineages are MAGEB4, OR56A5, and TRAPPC13. Each is linked with DOCK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOCK9-to-partner and partner-to-DOCK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by DOCK9-low versus DOCK9-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK9→partner) and Y-score (partner→DOCK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAGEB4 →	+0.004	+4.058	<.001	.007	3	2
LUNG_SCLC	OR56A5 →	+0.200	+3.662	<.001	.009	3	2
LARGE_INTESTINE	TRAPPC13 →	+0.391	+3.459	.007	.001	3	2
LARGE_INTESTINE	C1orf109 →	+0.640	+3.459	.001	.001	3	2
LARGE_INTESTINE	ZNHIT6 →	+0.495	+3.409	.002	<.001	3	2
LARGE_INTESTINE	ALDH6A1 →	+0.939	+2.386	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 586 associations by consensus.

MAGEB4 by DOCK9 expression — LUNG_SCLC

Explore this box plot interactively →