Across TCGA pan-cancer cohorts, DOCK8-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DOCK8-AS1 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DOCK8-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DOCK8-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, KIRP, and LUSC are the cancer types where DOCK8-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.710	0.540	<.001	152	view →
KIRP	OS	Tertile	II,III,IV	0.858	0.462	<.001	80	view →
LUSC	DFS	Tertile	II,III,IV	0.600	0.794	.003	42	view →
UVM	DFS	Quartile	All	0.904	0.495	.016	41	view →
MESO	DFS	Tertile	II,III,IV	0.508	0.299	.010	38	view →
DLBC	DFS	Median	IV	0.412	1.000	.006	38	view →
BLCA	OS	Quartile	All	0.810	0.592	<.001	37	view →
ACC	DFS	Median	All	0.311	0.592	.003	24	view →
CESC	DFS	Tertile	II,III,IV	0.678	0.843	.014	18	view →
LGG	DFS	Quartile	All	0.733	0.888	.008	14	view →
ESCA	DFS	Tertile	IV	0.242	0.704	.024	14	view →
SKCM	OS	Tertile	IV	0.706	0.173	.010	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: DOCK8-AS1 tumor-vs-normal RNA expression · all DOCK8-AS1 data types