DOCK7

Across TCGA cell cohorts, DOCK7 mutation is significantly associated with the RNA expression of many other genes, with 1,155 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK7-associated genes across cancer lineages are TLX3, TRIM49D1, and OTC. Each is linked with DOCK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOCK7-to-partner and partner-to-DOCK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLX3 grouped by DOCK7-low versus DOCK7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK7→partner) and Y-score (partner→DOCK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TLX3 →	+1.060	+2.681	.006	.008	3	2
UPPER_AERODIGESTIVE_TRACT	TRIM49D1 →	+0.098	+3.870	<.001	.003	3	2
BLOOD_Leukemia	OTC →	+0.059	+2.681	<.001	.008	3	2
LARGE_INTESTINE	TRMU →	+0.690	+2.502	<.001	.005	3	2
LARGE_INTESTINE	AHSA1 →	+0.484	+2.386	<.001	.007	3	2
LARGE_INTESTINE	RNF8 →	+0.493	+3.169	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,155 associations by consensus.

TLX3 by DOCK7 expression — BLOOD_Leukemia

Explore this box plot interactively →