DOCK6

Across TCGA pan-cancer cohorts, DOCK6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DOCK6 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DOCK6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DOCK6 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and UCEC are the cancer types where DOCK6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.924	.021	18	view →
CCRCC	DFS	Median	III,IV	0.842	0.522	.004	8	view →
UCEC	OS	Median	II,III,IV	0.659	0.928	.036	8	view →
HNSC	DFS	Tertile	All	0.990	0.905	.027	5	view →
LUAD	DFS	Quartile	All	0.559	1.000	.023	3	view →
LSCC	DFS	Median	III,IV	0.651	0.938	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DOCK6–COAD (DFS)

Open the COAD breakdown →