DOCK6

Across TCGA patient cohorts, DOCK6 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK6-associated genes across cancer lineages are Fibronectin, ATM, and ERK2. Each is linked with DOCK6 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK6-to-partner and partner-to-DOCK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by DOCK6-low versus DOCK6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK6→partner) and Y-score (partner→DOCK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Fibronectin →	+0.759	+2.816	.004	.036	3	3
COAD	ATM →	-0.461	-1.798	.001	.026	3	3
UCEC	ERK2 →	+0.135	+1.530	.008	.003	3	3
UCEC	c-Met →	-0.186	-1.734	.019	<.001	3	3
BLCA	Notch1 →	-0.199	-2.321	.007	.035	3	2
STAD	FoxM1 →	+0.271	+2.201	.017	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Fibronectin by DOCK6 expression — LUSC

Explore this box plot interactively →