DOCK5

Across TCGA pan-cancer cohorts, DOCK5 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DOCK5 data layer compared with 30 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher DOCK5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DOCK5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCS, BLCA, and MESO are the cancer types where DOCK5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.104	0.688	<.001	36	view →
BLCA	OS	Median	All	0.202	0.725	<.001	24	view →
MESO	DFS	Median	All	0.096	0.369	.007	18	view →
UCEC	DFS	Median	All	0.911	0.595	.005	18	view →
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	12	view →
SARC	OS	Median	All	0.174	0.745	.005	6	view →
LGG	OS	Median	All	0.295	0.799	.007	3	view →
GBM	DFS	Median	All	0.406	0.185	.031	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
STAD	DFS	Median	III,IV	0.836	0.337	.046	3	view →
HNSC	OS	Median	IV	0.176	0.639	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DOCK5–UCS (OS)

Open the UCS breakdown →