DOCK5

Across TCGA cell cohorts, DOCK5 mutation is significantly associated with the RNA expression of many other genes, with 1,323 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DOCK5-associated genes across cancer lineages are SKA1, TTK, and TAF5. Each is linked with DOCK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK5-to-partner and partner-to-DOCK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by DOCK5-low versus DOCK5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK5→partner) and Y-score (partner→DOCK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SKA1 →	+0.741	+2.265	.001	.001	3	3
LARGE_INTESTINE	TTK →	+0.529	+2.949	.002	<.001	3	3
LARGE_INTESTINE	TAF5 →	+0.366	+2.265	.007	.001	3	3
CNS	ZNF367 →	+0.713	+3.321	.005	.007	2	3
BLOOD_Leukemia	POLDIP3 →	+0.467	+3.366	.007	.002	3	2
BLOOD_Leukemia	METTL4 →	+0.540	+2.380	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,323 associations by consensus.

SKA1 by DOCK5 expression — LARGE_INTESTINE

Explore this box plot interactively →