DOCK4

Across TCGA pan-cancer cohorts, DOCK4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DOCK4 data layer compared with 24 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DOCK4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DOCK4 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

HNSC, PDAC, and GBM are the cancer types where DOCK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.442	0.803	.005	16	view →
PDAC	DFS	Quartile	All	0.703	0.867	.002	15	view →
GBM	DFS	Quartile	All	0.565	0.225	.004	11	view →
COAD	DFS	Quartile	III,IV	0.454	1.000	.038	6	view →
LSCC	DFS	Quartile	II,III,IV	0.512	1.000	.005	5	view →
CCRCC	DFS	Quartile	II,III,IV	0.752	0.409	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DOCK4–HNSC (DFS)

Open the HNSC breakdown →