DOCK4

Across TCGA patient cohorts, DOCK4 mutation is significantly associated with the RNA expression of many other genes, with 7,931 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK4-associated genes across cancer lineages are MND1, COQ3, and SKA1. Each is linked with DOCK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both DOCK4-to-partner and partner-to-DOCK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MND1 grouped by DOCK4-low versus DOCK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK4→partner) and Y-score (partner→DOCK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MND1 →	+0.758	+2.054	<.001	<.001	3	5
STAD	COQ3 →	+0.445	+2.502	.002	.001	3	5
COAD	SKA1 →	+0.753	+2.750	<.001	<.001	3	4
UCEC	SLC13A3 →	-0.347	-1.412	.002	<.001	3	4
LUAD	TEDC2 →	+0.712	+3.486	.001	.002	3	4
UCEC	PHAX →	+0.442	+1.254	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,931 associations by consensus.

MND1 by DOCK4 expression — UCEC

Explore this box plot interactively →