DOCK4

Across TCGA patient cohorts, DOCK4 mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK4-associated genes across cancer lineages are Cyclin-B1, FoxM1, and Cyclin-E2. Each is linked with DOCK4 in more than 6 cancer types. Because this analysis shows association rather than direction, both DOCK4-to-partner and partner-to-DOCK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DOCK4-low versus DOCK4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK4→partner) and Y-score (partner→DOCK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.549	+2.700	.003	.005	2	7
STAD	FoxM1 →	+0.324	+2.000	.002	.030	3	5
SKCM	Cyclin-E2 →	+0.196	+3.321	.001	.009	3	4
LUSC	GSK3-a-b →	+0.186	+3.468	.018	.002	3	3
LUSC	Collagen-VI →	-0.294	-3.450	.028	.005	3	3
LUSC	53BP1 →	+0.415	+2.331	.028	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

Cyclin-B1 by DOCK4 expression — STAD

Explore this box plot interactively →