DOCK4

Across TCGA cell cohorts, DOCK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,014 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DOCK4-associated GO terms across cancer lineages are Positive regulation of focal adhesion assembly, Host-mediated perturbation of viral process, and White fat cell proliferation. Each is linked with DOCK4 in more than 7 cancer types. Because this analysis shows association rather than direction, both DOCK4-to-partner and partner-to-DOCK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of focal adhesion assembly grouped by DOCK4-low versus DOCK4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK4→partner) and Y-score (partner→DOCK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of focal adhesion assembly →	+0.114	+1.428	.003	.001	3	8
STOMACH	Host-mediated perturbation of viral process →	+0.076	+1.865	.007	.003	2	8
URINARY_TRACT	White fat cell proliferation →	-1.202	-1.784	.002	.003	3	7
UPPER_AERODIGESTIVE_TRACT	Peptidyl-serine modification →	+0.066	+1.176	.002	.001	3	7
BLOOD_Lymphoma	Negative regulation of smooth muscle contraction →	-0.217	-1.060	<.001	<.001	3	7
PANCREAS	DNA-templated transcription termination →	+0.072	+1.733	.003	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,014 associations by consensus.

Positive regulation of focal adhesion assembly by DOCK4 expression — SKIN

Explore this box plot interactively →