DOCK4

Across TCGA cell cohorts, DOCK4 mutation is significantly associated with the RNA expression of many other genes, with 1,560 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK4-associated genes across cancer lineages are RANGRF, MRM3, and NAA38. Each is linked with DOCK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK4-to-partner and partner-to-DOCK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RANGRF grouped by DOCK4-low versus DOCK4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK4→partner) and Y-score (partner→DOCK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RANGRF →	+0.447	+2.459	.006	.003	3	3
LARGE_INTESTINE	MRM3 →	+0.611	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	NAA38 →	+0.871	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	LRRC39 →	+0.354	+1.807	.003	.003	3	2
SKIN	PSMC5 →	+0.444	+3.169	.005	.009	3	2
BLOOD_Lymphoma	OR52B2 →	+0.024	+3.714	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,560 associations by consensus.

RANGRF by DOCK4 expression — LARGE_INTESTINE

Explore this box plot interactively →