DOCK3

Across TCGA cell cohorts, DOCK3 mutation is significantly associated with the RNA expression of many other genes, with 1,338 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK3-associated genes across cancer lineages are HBS1L, FBXO30, and GNAI3. Each is linked with DOCK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK3-to-partner and partner-to-DOCK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBS1L grouped by DOCK3-low versus DOCK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK3→partner) and Y-score (partner→DOCK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HBS1L →	+0.586	+2.700	.002	.001	3	3
LARGE_INTESTINE	FBXO30 →	+0.438	+1.808	<.001	.001	3	3
SKIN	GNAI3 →	+0.477	+3.169	<.001	.006	3	3
SKIN	LRRC40 →	+0.483	+2.265	.001	.001	3	3
LARGE_INTESTINE	MAPK8 →	+0.643	+2.000	<.001	.004	3	3
LARGE_INTESTINE	FBXL4 →	+0.497	+2.212	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,338 associations by consensus.

HBS1L by DOCK3 expression — LARGE_INTESTINE

Explore this box plot interactively →