DOCK2

Across TCGA pan-cancer cohorts, DOCK2 Mutation is linked to patient survival in 14 of 34 cancer types, making it a survival-associated DOCK2 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DOCK2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DOCK2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

ACC, UCEC, and THYM are the cancer types where DOCK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
UCEC	DFS	Median	All	0.962	0.601	<.001	36	view →
THYM	OS	Median	All	0.604	0.975	<.001	30	view →
READ	OS	Median	II,III,IV	0.111	0.919	<.001	27	view →
LIHC	OS	Median	All	0.245	0.528	<.001	17	view →
HNSC	DFS	Median	All	1.000	0.344	.023	13	view →
LAML	DFS	Median	All	0.140	0.582	.020	12	view →
COAD	OS	Median	IV	0.045	0.659	<.001	12	view →
SKCM	DFS	Median	II,III,IV	0.908	0.554	.015	12	view →
LGG	DFS	Median	All	0.080	0.826	<.001	6	view →
PAAD	DFS	Median	All	0.100	0.505	.004	6	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

DOCK2–ACC (DFS)

Open the ACC breakdown →