DOCK2

Across TCGA pan-cancer cohorts, DOCK2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DOCK2 data layer compared with 22 for mass-spec protein and 14 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DOCK2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DOCK2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where DOCK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.715	1.000	.012	96	view →
PDAC	OS	Quartile	III,IV	0.160	1.000	.006	17	view →
LUAD	DFS	Quartile	All	0.865	0.459	<.001	16	view →
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
CCRCC	DFS	Median	III,IV	0.745	0.964	.005	6	view →
GBM	OS	Quartile	All	0.335	0.551	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DOCK2–COAD (DFS)

Open the COAD breakdown →