DOCK2

Across TCGA patient cohorts, DOCK2 mutation is significantly associated with the RNA expression of many other genes, with 9,128 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DOCK2-associated genes across cancer lineages are MRPS2, NOP10, and TUBB4B. Each is linked with DOCK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DOCK2-to-partner and partner-to-DOCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS2 grouped by DOCK2-low versus DOCK2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK2→partner) and Y-score (partner→DOCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MRPS2 →	+0.436	+2.095	<.001	<.001	3	6
COAD	NOP10 →	+0.402	+2.100	<.001	<.001	3	6
STAD	TUBB4B →	+0.498	+2.411	<.001	<.001	3	6
STAD	TRAPPC4 →	+0.416	+2.411	<.001	<.001	3	6
STAD	IER3IP1 →	+0.514	+2.821	<.001	<.001	3	6
UCEC	RITA1 →	+0.266	+1.201	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,128 associations by consensus.

MRPS2 by DOCK2 expression — STAD

Explore this box plot interactively →