DOCK2

Across TCGA patient cohorts, DOCK2 mutation is significantly associated with the total protein of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK2-associated genes across cancer lineages are ACC1, 4E-BP1, and INPP4B. Each is linked with DOCK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both DOCK2-to-partner and partner-to-DOCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by DOCK2-low versus DOCK2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK2→partner) and Y-score (partner→DOCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ACC1 →	+0.274	+1.461	.047	.013	3	5
STAD	4E-BP1 →	+0.361	+2.938	<.001	<.001	3	5
COAD	INPP4B →	-0.356	-2.450	.002	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+1.050	+1.824	<.001	.013	3	4
STAD	ACVRL1 →	-0.188	-2.438	.005	<.001	3	3
UCEC	eEF2 →	+0.261	+1.765	.003	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

ACC1 by DOCK2 expression — STAD

Explore this box plot interactively →