DOCK2

Across TCGA cell cohorts, DOCK2 mutation is significantly associated with the RNA expression of many other genes, with 1,616 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK2-associated genes across cancer lineages are TRAPPC13, TTC33, and RPS3A. Each is linked with DOCK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK2-to-partner and partner-to-DOCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAPPC13 grouped by DOCK2-low versus DOCK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK2→partner) and Y-score (partner→DOCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRAPPC13 →	+0.428	+2.212	<.001	<.001	3	3
LARGE_INTESTINE	TTC33 →	+0.576	+2.212	<.001	<.001	3	3
LARGE_INTESTINE	RPS3A →	+0.463	+2.212	.007	<.001	3	3
LARGE_INTESTINE	SASS6 →	+0.480	+1.458	<.001	.009	3	3
LARGE_INTESTINE	SCAI →	+0.500	+1.894	<.001	.001	3	3
URINARY_TRACT	HIGD2B →	+0.107	+3.769	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,616 associations by consensus.

TRAPPC13 by DOCK2 expression — LARGE_INTESTINE

Explore this box plot interactively →