DOCK11

Across TCGA pan-cancer cohorts, DOCK11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DOCK11 data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DOCK11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DOCK11 expression acts as an unfavorable survival marker.

GBM, HNSC, and PDAC are the cancer types where DOCK11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.234	0.637	.001	18	view →
HNSC	DFS	Median	All	0.909	0.994	.005	15	view →
PDAC	OS	Quartile	III,IV	0.526	1.000	.040	7	view →
CCRCC	DFS	Quartile	All	0.467	1.000	.004	3	view →
LSCC	DFS	Quartile	II,III,IV	0.557	0.927	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DOCK11–GBM (OS)

Open the GBM breakdown →