DOCK10

Across TCGA pan-cancer cohorts, DOCK10 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DOCK10 data layer compared with 19 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DOCK10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DOCK10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

KIRC, UCEC, and CESC are the cancer types where DOCK10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.054	0.806	<.001	44	view →
UCEC	DFS	Median	All	0.953	0.819	.002	36	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
BRCA	OS	Median	III,IV	0.200	0.833	.004	12	view →
STAD	DFS	Median	IV	0.093	0.479	.007	12	view →
PRAD	DFS	Median	All	0.817	0.934	.019	6	view →
ESCA	OS	Median	II,III,IV	0.268	0.549	.040	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
GBM	DFS	Median	All	0.799	0.245	.031	3	view →
BLCA	DFS	Median	IV	0.174	0.473	.034	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DOCK10–KIRC (OS)

Open the KIRC breakdown →