DOCK10

Across TCGA pan-cancer cohorts, DOCK10 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DOCK10 data layer compared with 19 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DOCK10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DOCK10 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

COAD, LUAD, and HNSC are the cancer types where DOCK10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.920	1.000	.034	42	view →
LUAD	DFS	Tertile	All	0.804	0.421	<.001	20	view →
HNSC	DFS	Median	II,III,IV	0.677	0.897	.004	15	view →
PDAC	DFS	Tertile	III,IV	0.793	0.325	.010	9	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
GBM	OS	Quartile	All	0.342	0.623	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DOCK10–COAD (DFS)

Open the COAD breakdown →