DOCK1

Across TCGA pan-cancer cohorts, DOCK1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DOCK1 data layer compared with 20 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DOCK1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DOCK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, UCEC, and UCS are the cancer types where DOCK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.309	0.700	<.001	36	view →
UCEC	DFS	Median	All	0.864	0.604	<.001	36	view →
UCS	OS	Median	III,IV	0.104	0.591	.004	24	view →
OV	DFS	Median	II,III,IV	0.219	0.542	.010	18	view →
BRCA	DFS	Median	III,IV	0.230	0.796	.004	12	view →
LUSC	OS	Median	II,III,IV	0.240	0.735	.002	12	view →
BLCA	OS	Median	III,IV	0.116	0.588	<.001	12	view →
SARC	DFS	Median	All	0.107	0.595	<.001	6	view →
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
ACC	DFS	Median	All	0.112	0.544	.042	3	view →
SKCM	DFS	Median	II,III,IV	0.818	0.538	.012	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DOCK1–HNSC (DFS)

Open the HNSC breakdown →