DOCK1

Across TCGA pan-cancer cohorts, DOCK1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DOCK1 data layer compared with 20 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DOCK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DOCK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where DOCK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.803	0.346	<.001	34	view →
UCEC	OS	Median	III,IV	0.311	1.000	.001	28	view →
LUAD	OS	Quartile	III,IV	1.000	0.316	.024	5	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
LSCC	OS	Quartile	III,IV	0.531	0.989	.037	2	view →
GBM	OS	Quartile	All	0.847	0.593	.042	1	view →
HNSC	OS	Median	All	0.994	0.942	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DOCK1–CCRCC (DFS)

Open the CCRCC breakdown →