DOCK1

Across TCGA pan-cancer cohorts, DOCK1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DOCK1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where DOCK1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DOCK1 is over-expressed in tumor, although a few such as LSCC and CCRCC show the opposite, repressed pattern.

LSCC, CCRCC, and HNSC are the cancer types where DOCK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOCK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	−0.521	<.001	9	view →
CCRCC	Male	II,III,IV	−0.173	<.001	9	view →
HNSC	All	All	−0.120	.003	9	view →
LUAD	Female	II,III,IV	−0.301	<.001	8	view →
COAD	Female	All	−0.165	<.001	5	view →
PDAC	All	II,III,IV	+0.198	.001	4	view →
OV	All	All	−0.599	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DOCK1–LSCC

Open the LSCC breakdown →