DOCK1

Across TCGA cell cohorts, DOCK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,749 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DOCK1-associated GO terms across cancer lineages are Regulation of hippo signaling, Negative regulation of hippo signaling, and Retrograde transport, endosome to Golgi. Each is linked with DOCK1 in more than 14 cancer types. Because this analysis shows association rather than direction, both DOCK1-to-partner and partner-to-DOCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by DOCK1-low versus DOCK1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK1→partner) and Y-score (partner→DOCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of hippo signaling →	+0.076	+0.875	.002	.003	1	15
URINARY_TRACT	Negative regulation of hippo signaling →	+0.095	+0.993	.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Retrograde transport, endosome to Golgi →	+0.073	+0.852	<.001	<.001	3	12
BONE	Regulation of cell-substrate junction organization →	+0.172	+1.408	<.001	<.001	3	12
KIDNEY	Cytosolic transport →	+0.074	+0.881	<.001	.002	2	12
LARGE_INTESTINE	Post-Golgi vesicle-mediated transport →	+0.041	+0.814	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,749 associations by consensus.

Regulation of hippo signaling by DOCK1 expression — URINARY_TRACT

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