DOCK1

Across TCGA cell cohorts, DOCK1 mutation is significantly associated with the RNA expression of many other genes, with 1,177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK1-associated genes across cancer lineages are MFN2, CHRM1, and CCKAR. Each is linked with DOCK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK1-to-partner and partner-to-DOCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFN2 grouped by DOCK1-low versus DOCK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK1→partner) and Y-score (partner→DOCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MFN2 →	+0.629	+3.321	.001	.002	3	3
LUNG_NSCLC_LUSC	CHRM1 →	+0.330	+3.321	.005	.006	3	2
BLOOD_Leukemia	CCKAR →	+0.019	+2.824	<.001	.007	3	2
LARGE_INTESTINE	FNDC3A →	+0.518	+2.949	.001	<.001	3	2
LARGE_INTESTINE	SEMA3G →	+0.592	+2.265	.008	.001	3	2
LARGE_INTESTINE	INTS9 →	+0.493	+3.169	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,177 associations by consensus.

MFN2 by DOCK1 expression — LARGE_INTESTINE

Explore this box plot interactively →