DOC2A

Across TCGA patient cohorts, DOC2A protein abundance is significantly associated with the RNA expression of many other genes, with 3,180 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DOC2A-associated genes across cancer lineages are SNRPD3, PRODH, and PIK3IP1. Each is linked with DOC2A in more than 1 cancer types. Because this analysis shows association rather than direction, both DOC2A-to-partner and partner-to-DOC2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOC2A versus SNRPD3 in GBM, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOC2A→partner) and Y-score (partner→DOC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD3 →	+0.429	+0.494	.003	.002	3	1
GBM	PRODH →	+1.148	+0.542	<.001	<.001	3	1
GBM	PIK3IP1 →	+0.454	+0.305	.003	.004	3	1
GBM	SOX10 →	+1.384	+0.582	<.001	<.001	3	1
GBM	SLC16A8 →	+0.800	+0.604	<.001	<.001	3	1
GBM	SEPTIN3 →	+1.487	+0.511	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,180 associations by consensus.

DOC2A vs SNRPD3 — GBM

Explore this scatter interactively →