DOC2A

Across TCGA patient cohorts, DOC2A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOC2A-associated genes across cancer lineages are ER-alpha_pS118, PDK1_pS241, and Lck. Each is linked with DOC2A in more than 1 cancer types. Because this analysis shows association rather than direction, both DOC2A-to-partner and partner-to-DOC2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by DOC2A-low versus DOC2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOC2A→partner) and Y-score (partner→DOC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	-0.435	-3.321	.020	.010	3	1
UCEC	PDK1_pS241 →	+0.192	+2.183	.031	.035	3	1
UCEC	Lck →	+0.400	+3.321	<.001	.010	2	1
UCEC	PCNA →	+0.286	+3.321	.011	.010	2	1
UCEC	PDCD4 →	-0.650	-2.990	.008	.036	2	1
UCEC	Caspase-7-cleavedD198 →	+1.592	+3.341	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ER-alpha_pS118 by DOC2A expression — UCEC

Explore this box plot interactively →